Future endeavors in -deficiency constitution research necessitate development of objective diagnostic tools, creation of animal models for investigation, conduct of high-evidence research on constitution-disease interactions, and exploration of the full scope of all nine constitutions. This will foster a more nuanced and objective understanding.
Clinical application of acupuncture prescriptions for functional gastrointestinal disorders (FGIDs) will be assessed, investigating the special, co-effect, or synergistic results produced based on the characteristics of chosen acupoints and corresponding acupuncture techniques.
By utilizing the search strategy, we examined six electronic bibliographic databases and formulated this overview's summary.
Acupuncture has been shown, through a wealth of research, to positively influence the treatment of Functional Gastrointestinal Disorders. However, the prescriptive intervention included varied single acupoints, compatible acupoints, and acupoints determined through expert opinion.
The core acupoints, including Tianshu (ST25), Zusanli (ST36), and Shangjuxu (ST37), focus on the application of specific acupoints, meridian points, and nerve segments. The study's observed two-way regulatory effect significantly influences the selection and prescription of acupoints for acupuncture treatment of FGIDs.
Fundamental acupoints, such as Tianshu (ST25), Zusanli (ST36), and Shangjuxu (ST37), demonstrate the significance of targeted acupoints, meridian points, and nerve segments, and the bi-directional regulation demonstrated in this study serves as a foundational principle for the selection of acupoints and creation of acupuncture protocols for FGIDs.
Employing a combined strategy of meta-analysis and bioinformatics, the preliminary exploration of the potential mechanism of Yinyanghuo and its extract in COPD treatment will be undertaken.
First, a meta-analytic review was undertaken. A systematic search strategy, combining subject terms and keywords, was employed to explore Chinese and English Yinyanghuo literature on COPD treatment. The included studies underwent assessment by the SYRCLE risk bias assessment tool prior to the review manager software's use in combining effect quantities for statistical analysis. The active ingredients and their respective targets of Yinyanghuo were identified using bioinformatics techniques, and shared genes were found by aligning and comparing them with COPD targets. The model, based on medicinal materials, compounds, and targets, was developed, and its significant pathways were labeled. In conclusion, the targeted core component was secured to its vital chemical compounds.
Eight studies were evaluated within the framework of the meta-analysis. The results of the study clearly demonstrate that the Yinyanghuo (Herba Epimedii Brevicornus) treatment group significantly reduced the levels of pro-inflammatory markers like tumor necrosis factor- (TNF-) and interleukin (IL)-8, while increasing the presence of anti-inflammatory and antioxidant factors, including IL-10 and phospho-protein kinase B (p-AKT) in the COPD model. This difference was statistically significant (all P < 0.05). Bioinformatics research on Yinyanghuo (Herba Epimedii Brevicornus) identified 23 active components and a total of 102 target genes; 17 compounds and 63 targets from this analysis displayed a marked link to COPD. Metabolism inhibitor TNF signaling, PI3K/Akt signaling, cancer signaling, inflammatory reactions, oxidative stress, and tumor-associated pathways emerged as significant results in the enrichment analysis. Analysis of molecular docking simulations for the top 5 components of 24-epicampesterol against 10 core targets, including IL-6, demonstrated binding energies all falling below 50 kcal/mol, suggesting strong binding potential.
Results from bioinformatics and meta-analysis indicate Yinyanghuo and its components might ameliorate COPD by counteracting inflammatory and oxidative stress processes. Initial research indicates the feasibility of Yinyanghuo as a natural therapeutic agent for COPD.
The therapeutic effect of Yinyanghuo and its components on COPD, as indicated by meta-analysis and bioinformatics results, may be linked to their ability to counteract inflammation and oxidative stress. periprosthetic joint infection These findings provide an initial framework for exploring Yinyanghuo as a natural COPD preventative and curative agent.
Traditional Chinese Medicine, or a combination with Western approaches, treats 50% of knee osteoarthritis (KOA) cases in China, thus demanding objective evaluation of its effectiveness. For prospective clinical trials, multi-source data collection, processing, and fusion were the chosen approaches, with 150 KOA patients and 100 healthy individuals as the study subjects. Various instruments, including a tongue inspection app, infrared device, and channel instrument, were employed for data acquisition. The processes of data analysis, screening, fusion, and modeling were applied to the multi-source data. A customized information platform, combined with traditional clinical tests in this study, supports convenient clinical testing, medical follow-up, and prompt statistical data analysis feedback.
Patients with malignant tumors who undergo radical mastectomy might experience a reduction in cellular immune function, which can significantly impact their quality of life (QOL). Immune suppression is a recurring problem that results in numerous complications and adverse reactions within the adjuvant therapy administered after a radical mastectomy for breast cancer. Currently, few remedies have been definitively proven to effectively counteract immune system suppression. For this reason, the formulation of a novel treatment protocol is essential. Within the scope of clinical practice, the press needle is commonly used. Despite this, the impact of press needles on the immune system after operation has been explored in only a limited number of studies. This research project seeks to determine the relationship between press needle usage and immune function and quality of life in women diagnosed with breast cancer who have undergone radical mastectomy. In this study, a single-center, randomized, and single-blinded clinical trial will be performed. 78 eligible patients, in a 11:1 ratio, are to be randomized into either the press needle group or the sham press needle group. Within the treatment phase, patients will receive verum press needle or sham press needle five times a week for two consecutive weeks. Evaluations of the primary outcomes will involve measuring the concentration of CD8+, CD4+, CD3+, and CD4+/CD8+ T cells in the peripheral blood. The EORTC QLQ-C30 quality of life questionnaire, in conjunction with the Karnofsky Performance Scale, will be used to assess changes in patient quality of life, which will be considered secondary outcome measures. Furthermore, an evaluation of the 5-year survival rate and the recurrence rate will be conducted. An evaluation of safety and adverse events is part of the protocol for each visit. Clinical evidence for the effects and safety of press needles on immune function and quality of life will be produced in this ongoing study, which compares press needle to sham needle in patients after breast cancer resection. The registration of this trial is formally recorded at the Chinese Clinical Trial Registry under the identifier ChiCTR2000040100. November 21st, 2020, marked the date of registration.
The microbial community structure of various tongue coating types was examined in patients with chronic gastritis to explore the correlation between the tongue's microbiome and oral health.
To examine the dynamic interplay and correlations of microbial populations, 16S rDNA gene sequencing and bioinformatics were applied to patients with chronic gastritis, healthy individuals, and patients categorized by tongue fur characteristics. Moreover, the meeting addressed the relationship between the intensity of gastritis and the microbial community present on the surface of the tongue.
A significant difference in the microbial diversity of tongue fur was apparent in patients with chronic gastritis, in contrast to healthy controls. A notable distinction in bacterial community diversity and relative abundance was found between patients with extra tongue fur and healthy controls, yet no variation was seen in healthy subjects. The dominant bacterial groups in tongue fur samples, characterized by relative abundances exceeding 1% and falling below 0.05%, included 12 phyla, such as and , and 256 genera, such as and .
A connection existed between the presence of tongue fur and the variations in oral flora, particularly in patients with chronic gastritis. Accordingly, the notable microbial composition of the oral cavity could potentially stimulate further research exploring the correlation between tongue examination and oral microbiota in patients with chronic gastritis.
The oral flora of patients with persistent gastritis exhibited modifications that were observed to be related to the presence of tongue fur. Streptococcal infection In consequence, the substantial microbial community warrants further investigation into the connection between tongue observation and oral microbiota in patients with chronic gastritis.
A study evaluating the clinical efficacy of acupuncture, applied along fascial pathways, meridians, and nerves, combined with ultrasound-guided nerve blockade for treating postherpetic neuralgia.
At the Xiyuan Hospital's Department of Pain, within the China Academy of Chinese Medical Sciences, 61 outpatients with post-herpes zoster neuralgia of the chest and back were enrolled for the study between May 2019 and June 2021. They were put into two groups through a random procedure. Thirty-one patients in the control group underwent ultrasound-guided thoracic paravertebral nerve block (PVB) treatment only. One patient discontinued the study, leaving thirty participants. Meanwhile, thirty patients in the observation group received acupuncture on fascia, meridians, and nerves, plus ultrasound-guided PVB. Both the control and observation groups received weekly treatment for four weeks.